Our lab aims to advance the field of cancer research through innovation and collaboration while maintaining a commitment to equity, diversity, and inclusion.
In the Sabatinos Lab at Toronto Metropolitan University, we work towards identifying how responses to DNA damage and replication stress can impact cancer cell survival. We also aim to identify novel drugs to implement in anti-microbial, anti-fungal, and anti-cancer contexts.
We work primarily in Schizosaccharomyces pombe and mammalian cell lines. In fission yeast we model disease genotypes building a foundational understanding of the impact various genes may have in the presence of drugs. In mammalian cell lines, cancer and non-cancerous, are leveraged to assess at a biologically relevant level the effects that drugs have using various cellular and molecular biology approaches.
Model Organism
S. pombe has highly conserved cellular processes with humans making it a great foundation for research.
Cancer Cell Lines
Cancer cell lines allow for advances in research as they provide relevant genetic background for experiments.
Drug Treatment
Testing various drugs and compounds in yeast and cancer cells allows us to identify optimal therapeutic approaches.
Molecular Analysis
A variety of a molecular biology assays allow us to identify critical markers in context of disease and how they change with treatment.
News from the bench….
A passionate group of researchers dedicated to identifying the effects of novel drugs on stress in cancer.
The Sabatinos Lab works with breast cancer and pancreatic cell lines to investigate the impact that novel drugs and combinatory treatment have on cancer cell viability. Novel drugs of interest are associated with the induction of DNA damage and replication stress and can be identified and characterized through large screens in S. pombe.
Research Interests
I was taught that the way of progress was neither swift nor easy.
Marie Curie
Sabatinos Lab 